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Cell Cycle/Checkpoint ROCK Thiazovivin

Thiazovivin

Catalog No. T2155   CAS 1226056-71-8
Purity 98.75% Datasheet MSDS

Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.

Thiazovivin, CAS 1226056-71-8
Pack Size Availability Price/USD Quantity
1 mg In stock 42.00
2 mg In stock 55.00
5 mg In stock 77.00
10 mg In stock 131.00
25 mg In stock 247.00
50 mg In stock 446.00
100 mg In stock 725.00
1 mL * 10 mM (in DMSO) In stock 84.00
Bulk Size: Please Quote for Discount
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Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
Targets&IC50 ROCK :ic50 ~0.5μM,  
Synonyms
Purity 98.75%
Appearance solid
Molecular Weight 311.36
Formula C15H13N5OS
CAS No. 1226056-71-8

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 31.1 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL

Citations

References and Literature
1. Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8129-34. 2. Park S, et al. Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Anim Reprod Sci. 2015 Oct;161:47-57. 3. Hu K, et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011 Apr 7;117(14):e109-19.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Stem cell Differentiation Compound Library DNA Damage & Repair Compound Library Kinase Inhibitor Library TGF-beta/Smad Compound Library Cell cycle related Compound Library

Related Products

Related compounds with same targets
Y-27632 dihydrochloride RKI-1447 Capivasertib RKI-1313 Thiazovivin Tofacitinib Citrate AT13148 GSK429286A

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.