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Thiocolchicine

Catalog No. T41248 CAS 2730-71-4

Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

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Thiocolchicine, CAS 2730-71-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 672.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
Targets&IC50	Tubulin polymerization:0.7 µM(Ki), Tubulin polymerization:2.5 µM
In vitro	Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. Thiocolchicine inhibits cell proliferation of MDA-MB-231 and multidrug-resistant (MDR) MCF-7 ADRr breast cancer cells with IC50s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells with an IC50 of 50 nM[1]. Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively[2].

Molecular Weight	415.5
Formula	C22H25NO5S
CAS No.	2730-71-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (228.64 mM), Sonication is recommended.

References and Literature

1. R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13(1):19-33. 2. Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Microtubule-Targeted Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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SB-216 SS28 Vincristine sulfate Epothilone A BRD9876 Albendazole Podofilox Ansamitocin P 3'

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thiocolchicine 2730-71-4 Cytoskeletal Signaling Microtubule Associated breast LoVo/DX MDR-positive Microtubule/Tubulin inhibit MCF-7 leukemia Colchicine Apoptosis BALB/3T3 cancer A-549 LoVo Analogue Inhibitor inhibitor

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