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Tiagabine hydrochloride

Catalog No. T7000 CAS 145821-59-6

Synonyms: NO328 hydrochloride, NO050328 hydrochloride, TGB hydrochloride, Gabitril, Gabitril hydrochloride

Tiagabine hydrochloride (NO050328 hydrochloride) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

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Tiagabine hydrochloride Chemical Structure

Tiagabine hydrochloride, CAS 145821-59-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 113.00
100 mg	In stock	$ 203.00
200 mg	In stock	$ 331.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.77%

Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tiagabine hydrochloride (NO050328 hydrochloride) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
In vitro	Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[4].
In vivo	Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].

Synonyms	NO328 hydrochloride, NO050328 hydrochloride, TGB hydrochloride, Gabitril, Gabitril hydrochloride
Molecular Weight	412.01
Formula	C20H25NO2S2·HCl
CAS No.	145821-59-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41.2 mg/mL (100 mM)

H2O: 20.6 mg/mL (50 mM)

References and Literature

1. Hu RQ, et al. Brain Res. 1997, 753(2):260-8. 2. Angehagen M, et al. Neurochem Res. 2003, 28(2):333-40. 3. Iqbal S, et al. Brain Res. 2002, 946(2):162-70. 4. Chen L, et al. Exp Brain Res. 2003, 152(2):263-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Clinical Compound Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tiagabine hydrochloride 145821-59-6 Membrane transporter/Ion channel Neuroscience GABA Receptor NO050328 TGB NO-050328 Hydrochloride NO328 hydrochloride NO-050328 γ-Aminobutyric acid Receptor NO 050328 NO050328 Hydrochloride TGB Hydrochloride NO 328 Hydrochloride inhibit Tiagabine Hydrochloride NO-328 Hydrochloride NO328 Hydrochloride NO-328 Gabitril Hydrochloride NO 050328 Hydrochloride NO328 NO050328 hydrochloride TGB hydrochloride Gamma-aminobutyric acid Receptor Gabitril Tiagabine NO 328 Gabitril hydrochloride Inhibitor inhibitor

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