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Tinidazole

Catalog No. T0893   CAS 19387-91-8
Synonyms: CP12574

Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

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Tinidazole Chemical Structure
Tinidazole, CAS 19387-91-8
Pack Size Availability Price/USD Quantity
50 mg In stock $ 34.00
100 mg In stock $ 48.00
200 mg In stock $ 58.00
1 g In stock $ 90.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.
Synonyms CP12574
Molecular Weight 247.27
Formula C8H13N3O4S
CAS No. 19387-91-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46 mg/mL (186 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Narcisi EM, et al. Antimicrob Agents Chemother, 1996, 40(5), 1121-1125. 2. Fung HB, et al. Clin Ther, 2005, 27(12), 1859-1884. 3. Crowell AL, et al. Antimicrob Agents Chemother, 1996, 40(5), 1121-1125. 4. Meloni BP, et al. Trans R Soc Trop Med Hyg, 1990, 84(3), 375-379.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Anti-Bacterial Compound Library Approved Drug Library Anti-Infection Compound Library FDA-Approved Drug Library Bioactive Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max ReFRAME Related Library Drug-induced Liver Injury (DILI) Compound Library

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Keywords

Tinidazole 19387-91-8 Microbiology/Virology Antibacterial Antibiotic inhibit infections antimicrobial Inhibitor anaerobic CP 12574 Bacterial CP12574 CP-12574 bacteria inhibitor

 

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