Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 173.00 | |
50 mg | In stock | $ 289.00 | |
100 mg | In stock | $ 455.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect. |
Targets&IC50 | D2:7.0 μM |
In vivo | In ACTH-treated rats, Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test. In ACTH-treated rats, Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) [2]. |
Molecular Weight | 311.89 |
Formula | C15H18ClNS2 |
CAS No. | 1449686-84-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (160 mM)
DMSO: 41.67 mg/mL (133.60 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tipepidine hydrochloride 1449686-84-3 GPCR/G Protein Membrane transporter/Ion channel Neuroscience Dopamine Receptor Potassium Channel KcsA inhibit Tipepidine Inhibitor Tipepidine Hydrochloride inhibitor