Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 45.00 | |
10 mg | In stock | $ 72.00 | |
25 mg | In stock | $ 126.00 | |
50 mg | In stock | $ 197.00 | |
100 mg | In stock | $ 369.00 | |
500 mg | In stock | $ 869.00 | |
1 g | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM). |
Targets&IC50 | ErbB2:8 nM |
In vitro | Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. |
In vivo | In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1]. |
Synonyms | ARRY-380, Irbinitinib, ONT-380 |
Molecular Weight | 480.52 |
Formula | C26H24N8O2 |
CAS No. | 937263-43-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 87 mg/mL(181.1 mM)
Ethanol: 15 mg/mL (31.22 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tucatinib 937263-43-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER ARRY-380 Irbinitinib ONT 380 inhibit ErbB-1 HER1 ARRY 380 ARRY380 ONT-380 Epidermal growth factor receptor ONT380 Inhibitor inhibitor