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UC-1728

Catalog No. T17196   CAS 948304-40-3
Synonyms: t-TUCB

UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).

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UC-1728 Chemical Structure
UC-1728, CAS 948304-40-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 133.00
5 mg In stock $ 302.00
10 mg In stock $ 453.00
25 mg In stock $ 747.00
50 mg In stock $ 1,050.00
100 mg In stock $ 1,420.00
1 mL * 10 mM (in DMSO) In stock $ 355.00
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Purity: 99.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).
Targets&IC50 rabbit sHE:2 nM
In vivo Rabbits were treated by subcutaneous injection with the sEH inhibitor (UC1728, 3 mg/kg), or the vehicle control (PEG400) and uveitis was assessed at 6, 24 and 48 h post-intracameral LPS injection using a modified Hackett-McDonald scoring system.?Eyes treated by intra-cameral injection of PBS, or by aseptic preparation served as further controls.?Signs of inflammation in this model were mild and transient.?Treatment with UC1728 did not significantly reduce inflammation compared to animals treated with the PEG400 vehicle.?Blood levels of UC1728 were a thousand fold higher than the in vitro determined inhibitory potency (IC50) of the compound suggesting a significant degree of inhibition of sEH in the rabbit.?The lack of efficacy suggests that sEH or its substrates the EETs may not be involved in mediating inflammation in this model of uveitis[1].
Synonyms t-TUCB
Molecular Weight 438.4
Formula C21H21F3N2O5
CAS No. 948304-40-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (45.62 mM)

Related compound libraries

This product is contained In the following compound libraries:
Lipid Metabolism Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Metabolism Compound Library

Related Products

Related compounds with same targets
CUDA Valpromide CAY10640 AR-9281 GSK2256294A EC5026 1,3-Diphenylurea sEH inhibitor-7

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Keywords

UC-1728 948304-40-3 Metabolism Epoxide Hydrolase Inhibitor inhibit UC 1728 UC1728 t-TUCB inhibitor

 

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