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UVI 3003

Catalog No. T17209 CAS 847239-17-2

UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).

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UVI 3003, CAS 847239-17-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 255.00
50 mg	In stock	$ 428.00
100 mg	In stock	$ 639.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 99.94%

Biological Description

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Description	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).
Targets&IC50	RXRα:0.22 μM(Xenopus RXRα, in Cos7 cells), RXRα:0.24 μM(Human RXRα, in Cos7 cells)
In vitro	UVI3003 fully activates xPPARγ (EC50: 12.6 μM) and is almost completely inactive on hPPARγ and mPPARγ. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells [1][2].

Molecular Weight	436.58
Formula	C28H36O4
CAS No.	847239-17-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (229.05 mM), Sonification is recommended.

References and Literature

1. Zhu J, et al. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97. 2. Hebert SL, et al. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361(1):101-111.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Metabolism Disease Compound Library Bioactive Compound Library Neuronal Differentiation Compound Library Autophagy Compound Library Nuclear Receptor Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Metabolism Compound Library

Related Products

Related compounds with same targets

BMS 195614 AR7 AC-261066 Retinoic acid-d5 Liarozole LG-100064 KCL-286 AC-55649

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Keywords

UVI 3003 847239-17-2 Autophagy Metabolism Retinoid Receptor UVI3003 Retinoid X receptors RAR/RXR UVI-3003 Inhibitor Retinoic acid receptors inhibit inhibitor

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