Home Tools
Log in
Cart

Ulipristal acetate

Catalog No. T2527   CAS 126784-99-4
Synonyms: Ulipristal, CDB-2914

Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ulipristal acetate Chemical Structure
Ulipristal acetate, CAS 126784-99-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 45.00
10 mg In stock $ 61.00
50 mg In stock $ 126.00
100 mg In stock $ 198.00
200 mg In stock $ 297.00
1 mL * 10 mM (in DMSO) In stock $ 51.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.94%
Purity: 99.79%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception.
In vitro Ulipristal acetate blocks activin A modulation of fibronectin and vascular endothelial growth factor A (VEGF-A) mRNA expression in cultured myometrial and leiomyoma cells[2]. Ulipristal acetate decreases the DNA fragmentation at the 100-ng/mL dose and continuing up to the 10,000-ng/mL dose compared to those spermatozoa in the control group[3].
In vivo Ulipristal and CDB-4124 exhibit notable antiprogestational effects in vivo[1]. Ulipristal acetate has been shown to reduce the occurrence of fibroadenomas and adenocarcinomas in the mammary glands across all groups studied. At the highest administered dose in rats, ulipristal acetate exposure [AUC(0-24h)] is 67 times the human therapeutic exposure at 10 mg/day. Importantly, in mice, ulipristal acetate does not lead to an increase in tumor formation, even at exposures up to 313 times the therapeutic level. Adverse effects in mice are confined to weight changes in specific organs (liver, pituitary, thyroid/parathyroid glands, and epididymis) and minimal panlobular hepatocellular hypertrophy at a dose of 130 mg/kg/day[4]. Additionally, ulipristal acetate at doses of 1 mg/kg and 5 mg/kg causes a dose-dependent increase in endometrial thickening, observed by pathologists more frequently than in controls. There is also a minor decrease in secretory differentiation as the dose of ulipristal acetate increases, indicated by reduced sub- and supra-nuclear vacuolation[5].
Synonyms Ulipristal, CDB-2914
Molecular Weight 475.62
Formula C30H37NO4
CAS No. 126784-99-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (105.12 mM)

TargetMolReferences and Literature

1. Attardi BJ, et al. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Ma 2. Ciarmela P, et al. Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. Reprod Sci. 2014 Sep;21(9):1120-5. 3. Munuce MJ, et al. Effects of ulipristal acetate on sperm DNA fragmentation during in vitro incubation. Eur J Contracept Reprod Health Care. 2013 Oct;18(5):355-63. 4. Pohl O, et al. Carcinogenicity and chronic rodent toxicity of the selective progesterone receptor modulator ulipristal acetate. Curr Drug Saf. 2013 Apr;8(2):77-97. 5. Pohl O, et al. A 39-week oral toxicity study of ulipristal acetate in cynomolgus monkeys. Regul Toxicol Pharmacol. 2013 Jun;66(1):6-12.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Clinical Compound Library Anti-Aging Compound Library Drug-induced Liver Injury (DILI) Compound Library Anti-Cancer Compound Library Human Metabolite Library FDA-Approved Drug Library

Related Products

Related compounds with same targets
Norethindrone Desogestrel Etonogestrel Levonorgestrel Mifepristone Norgestimate Progesterone Nomegestrol acetate

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ulipristal acetate 126784-99-4 Autophagy Endocrinology/Hormones Others Progesterone Receptor Estrogen/progestogen Receptor NR3C3 inhibit CDB2914 Ulipristal Acetate anti-fertility anti-glucocorticoid CDB 2914 Inhibitor anti-progestational Ulipristal contraception leiomyoma uterine CDB-2914 emergency inhibitor

 

TargetMol