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VAF347

Catalog No. T13276   CAS 574759-62-9

VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.

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VAF347 Chemical Structure
VAF347, CAS 574759-62-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 77.00
10 mg In stock $ 122.00
25 mg In stock $ 222.00
50 mg In stock $ 372.00
100 mg In stock $ 556.00
500 mg In stock $ 1,220.00
1 mL * 10 mM (in DMSO) In stock $ 115.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
In vitro In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn[1]. VAF347 enhances retinoic acid-induced cell cycle arrest[1].
In vivo AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo[2].
Molecular Weight 349.74
Formula C17H11ClF3N3
CAS No. 574759-62-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17.85 mg/mL (51.05 mM), Sonification is recommended

TargetMolReferences and Literature

1. Ibabao CN, et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr 8;5:308-18. 2. B Paige Lawrence, et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood. 2008 Aug 15;112(4):1158-65.

Related compound libraries

This product is contained In the following compound libraries:
Transcription Factor-Targeted Compound Library Bioactive Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Immunology/Inflammation Compound Library

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YL-109 Carbidopa AHR antagonist 5 free base PD98059 SGA360 Tapinarof FICZ Brevifolincarboxylic acid

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Keywords

VAF347 574759-62-9 Immunology/Inflammation Aryl Hydrocarbon Receptor VAF-347 inhibit Inhibitor AhR VAF 347 inhibitor

 

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