Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 222.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 115.00 |
Description | VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects. |
In vitro | In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn[1]. VAF347 enhances retinoic acid-induced cell cycle arrest[1]. |
In vivo | AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo[2]. |
Molecular Weight | 349.74 |
Formula | C17H11ClF3N3 |
CAS No. | 574759-62-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 17.85 mg/mL (51.05 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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VAF347 574759-62-9 Immunology/Inflammation Aryl Hydrocarbon Receptor VAF-347 inhibit Inhibitor AhR VAF 347 inhibitor