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VU0453595

Catalog No. T29137   CAS 1432436-13-9
Synonyms: VU 0453595, VU-0453595

VU0453595 is a M1 positive allosteric modulator (PAM).

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VU0453595 Chemical Structure
VU0453595, CAS 1432436-13-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
2 mg In stock $ 63.00
5 mg In stock $ 97.00
10 mg In stock $ 163.00
25 mg In stock $ 318.00
50 mg In stock $ 493.00
100 mg In stock $ 719.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description VU0453595 is a M1 positive allosteric modulator (PAM).
Synonyms VU 0453595, VU-0453595
Molecular Weight 322.34
Formula C18H15FN4O
CAS No. 1432436-13-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (310.23 mM)

TargetMolReferences and Literature

1. Lv X, et al. M(1) muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Neuropharmacology. 2017 May 15;118:209-222. 2. Panarese JD, et al. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3822-5. 3. Ghoshal A, et al. Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology. 2016 Jan;41(2):598-610.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Keywords

VU0453595 1432436-13-9 Neuroscience AChR Muscarinic acetylcholine receptor modulator systemically allosteric VU 0453595 mAChR PAM positive inhibit VU-0453595 schizophrenia Inhibitor inhibitor

 

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