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Valbenazine

Catalog No. T7147 CAS 1025504-45-3

Synonyms: NBI-98854

Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.

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Valbenazine, CAS 1025504-45-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 46.00
2 mg	In stock	$ 67.00
5 mg	In stock	$ 135.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 447.00
50 mg	In stock	$ 647.00
100 mg	In stock	$ 923.00
1 mL * 10 mM (in DMSO)	In stock	$ 126.00

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Purity: 99.68%

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Description	Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.
In vivo	Valbenazine appeared to be well tolerated in adults with TD who received up to 48 weeks of treatment. In addition to long-term efficacy results, Suggest that valbenazine may be appropriate for the long-term management of TD regardless of underlying psychiatric diagnosis (SCHZ disorder or mood disorder)[1].
Animal Research	The pooled long-term exposure (LTE) population included valbenazine-treated subjects from 3 studies: KINECT; KINECT 3; KINECT4. Safety assessments included adverse events (AEs), laboratory tests, vital signs, electrocardiograms (ECGs), and extrapyramidal symptom (EPS) scales. Psychiatric stability was monitored using the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale for Schizophrenia (CDSS) (SCHZ subgroup), as well as the Montgomery-?sberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) (mood subgroup). All data were analyzed descriptively[1].

Synonyms	NBI-98854
Molecular Weight	418.57
Formula	C24H38N2O4
CAS No.	1025504-45-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (119.45 mM)

References and Literature

1. Josiassen R C , Kane J M , Liang G S , et al. Long-Term Safety and Tolerability of Valbenazine (NBI-98854) in Subjects with Tardive Dyskinesia and a Diagnosis of Schizophrenia or Mood Disorder[J]. Psychopharmacology bulletin, 2017, 47(3):61-68. 2. Factor S A , Remington G , Comella C L , et al. The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study[J]. The Journal of Clinical Psychiatry, 2017, 78(9).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max FDA-Approved Drug Library Ion Channel Inhibitor Library Pediatric Drug Library Orally Active Compound Library

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Keywords

Valbenazine 1025504-45-3 Membrane transporter/Ion channel Monoamine Transporter disease VMAT2 NBI 98854 monoamine transporter inhibit Huntington Inhibitor vesicular NBI-98854 NBI98854 inhibitor

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