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Valdecoxib

Catalog No. T0219   CAS 181695-72-7
Synonyms: SC 65872

Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.

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Valdecoxib Chemical Structure
Valdecoxib, CAS 181695-72-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 59.00
10 mg In stock $ 90.00
25 mg In stock $ 196.00
50 mg In stock $ 360.00
100 mg In stock $ 535.00
500 mg In stock $ 1,190.00
1 mL * 10 mM (in DMSO) In stock $ 54.00
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Purity: 99.89%
Purity: 97.66%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
Targets&IC50 COX-2:5 nM
In vitro Valdecoxib demonstrates significant efficacy in acute and chronic inflammation models in rats, with ED50 values of 0.06 mg/kg for carrageenan air-pouch inflammation, 5.9 mg/kg for paw edema, and 0.03 mg/kg for nonspecific arthritis. When administered alone, valdecoxib shows slow absorption in vivo, achieving a maximum inhibition of 16% in edema at 3 hours post-administration. In contrast, the valdecoxib complexes VALD-βCd and VALD-SBE7βCd exhibit high absorption rates, suppressing over 50% of edema within 1 hour, and achieving a maximum inhibition of 66% at 3 hours. Orally administered valdecoxib inhibits carrageenan-induced rat paw edema with an ED50 value of 10.2 mg/kg. In a rat model of nonspecific arthritis, oral valdecoxib shows chronic anti-inflammatory activity, with an ED50 of 0.032 mg/kg/day. Valdecoxib also inhibits prostaglandin production at the inflammation site in rats with carrageenan air-pouch inflammation when administered orally, with an ED50 value of 0.02 mg/kg.
In vivo Valdecoxib inhibits the production of PGE2 in plasma induced by lipopolysaccharides (IC50: 0.89 μM) and suppresses the generation of TxB2 in plasma (IC50: 25.4 μM). It binds to COX-2 with a Ka of 1.1×10^5 M/s and exhibits a strong overall saturable binding affinity to COX-2 of 2.6 nM. After 15 minutes (DP15), valdecoxib has a solubility percentage of 10.5%, while its hydrophilic derivatives (VALD-βCd, VALD-HPβCd, and VALD-SBE7βCd complexes) display significantly increased solubility percentages of 50%, 91%, and 93%, respectively.
Synonyms SC 65872
Molecular Weight 314.36
Formula C16H14N2O3S
CAS No. 181695-72-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.4 mg/mL (100 mM)

TargetMolReferences and Literature

1. Talley JJ, et al. J Med Chem, 2000, 43(5), 775-777. 2. Gierse JK, et al. J Pharmacol Exp Ther, 2005, 312(3), 1206-12012. 3. Hood WF, et al. Mol Pharmacol, 2003, 63(4), 870-877. 4. Rajendrakumar K, et al. Eur J Pharm Biopharm, 2005, 60(1), 39-46. 5. Zhang JY, et al. Drug Metab Dispos, 2003, 31(4), 491-501.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug-induced Liver Injury (DILI) Compound Library HIF-1 Signaling Pathway Compound Library Drug Repurposing Compound Library ReFRAME Related Library Pyroptosis Compound Library Inhibitor Library

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Keywords

Valdecoxib 181695-72-7 Immunology/Inflammation Neuroscience COX Inhibitor inhibit SC-65872 Cyclooxygenase SC65872 SC 65872 inhibitor

 

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