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Valganciclovir hydrochloride

Catalog No. T1533 CAS 175865-59-5

Synonyms: Valganciclovir HCl, Valcyt, Valcyte

Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, and viral replication.

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Valganciclovir hydrochloride Chemical Structure

Valganciclovir hydrochloride, CAS 175865-59-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 38.00
25 mg	In stock	$ 61.00
50 mg	In stock	$ 89.00
100 mg	In stock	$ 139.00
200 mg	In stock	$ 198.00
500 mg	In stock	$ 347.00
1 g	In stock	$ 516.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 99.79%

Purity: 98.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, and viral replication.
In vitro	Valganciclovir is efficiently absorbed through the gastrointestinal tract, with its bioavailability approximately 60% when taken orally after meals. Upon administration, both intestinal and hepatic esterases concurrently hydrolyze the two enantiomers of ganciclovir, inhibiting the replication of human cytomegalovirus.
In vivo	In cells infected with Cytomegalovirus (CMV), Valganciclovir is initially phosphorylated by viral protein kinase to its monophosphate form, then further phosphorylated by cellular kinases to produce its triphosphate form. This triphosphate is slowly metabolized within the cell. The phosphorylation process is dependent on viral kinase and preferentially occurs in virus-infected cells. Ganciclovir's antiviral activity is due to the triphosphate form of ganciclovir, which inhibits viral DNA synthesis. The ganciclovir triphosphate gets incorporated into the DNA, replacing many adenine bases, and hindering DNA synthesis as diester bonds take longer to form, thus diminishing the chain's stability.

Synonyms	Valganciclovir HCl, Valcyt, Valcyte
Molecular Weight	390.82
Formula	C14H23ClN6O5
CAS No.	175865-59-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 127.94mM

DMSO: 199.6 mM

References and Literature

1. Sugawara M, et al. J Pharm Sci, 2000, 89(6), 781-789. 2. Cvetković RS, et al. Drugs, 2005, 65(6), 859-878.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Infection Compound Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library Bioactive Compounds Library Max Orally Active Compound Library Anti-Viral Compound Library Bioactive Compound Library Nucleotide Compound Library

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Keywords

Valganciclovir hydrochloride 175865-59-5 Immunology/Inflammation Others Antiviral Inhibitor Cytomegalovirus CMV Valganciclovir Valganciclovir HCl Valcyt Valcyte inhibit Valganciclovir Hydrochloride inhibitor

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