Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 36.00 | |
50 mg | In stock | $ 48.00 | |
100 mg | In stock | $ 68.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes |
Targets&IC50 | PDE1:180 nM (IC50), PDE5:0.7 nM (IC50), PDE6:11 nM (IC50) |
In vivo |
After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10 mg or 20 mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P < 0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P < 0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P < 0.0001) and successful intercourse (P < 0.0001) compared with placebo. Vardenafil treatment was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment-emergent adverse events were primarily mild to moderate headache ( |
Molecular Weight | 525.06 |
Formula | C23H33ClN6O4S |
CAS No. | 224785-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (190.45 mM), sonification is recommended.
H2O: 100 mg/mL (190.45 mM)
You can also refer to dose conversion for different animals. More
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Vardenafil hydrochloride 224785-91-5 Metabolism PDE Vardenafil Hydrochloride PDE-5 inhibitors Vardenafil Endogenous Metabolite diabetes Zucker diabetic fatty (ZDF) rats dysfunction erectile dysfunction Pharmacokinetics Phosphodiesterase (PDE) inhibit selective Impotence Inhibitor smooth erectile muscle stimulation cGMP hepatitis inhibitor