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Vardenafil hydrochloride

Catalog No. T8405   CAS 224785-91-5

Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes

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Vardenafil hydrochloride Chemical Structure
Vardenafil hydrochloride, CAS 224785-91-5
Pack Size Availability Price/USD Quantity
25 mg In stock $ 36.00
50 mg In stock $ 48.00
100 mg In stock $ 68.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.86%
Purity: 99.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes
Targets&IC50 PDE1:180 nM (IC50), PDE5:0.7 nM (IC50), PDE6:11 nM (IC50)
In vivo After 12 weeks of treatment, a dose-dependent (P = 0.02) improvement in erections was noted for the GAQ, with 57 and 72% of men taking 10 mg or 20 mg vardenafil, respectively, reporting improved erections, in contrast to 13% after taking placebo (P < 0.0001). For the erectile function domain, dose-dependent (P = 0.03) final scores for the 10- and 20-mg dose were 17.1 and 19.0 compared with 12.6 for placebo (P < 0.0001). Both vardenafil doses significantly enhanced the rates of successful penetration (P < 0.0001) and successful intercourse (P < 0.0001) compared with placebo. Vardenafil treatment was effective in increasing intercourse success rates at all levels of baseline ED severity, at each level of plasma HbA(1c), and for type 1 and 2 diabetes. Treatment-emergent adverse events were primarily mild to moderate headache (
Molecular Weight 525.06
Formula C23H33ClN6O4S
CAS No. 224785-91-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (190.45 mM), sonification is recommended.

H2O: 100 mg/mL (190.45 mM)

TargetMolReferences and Literature

1. Irwin Goldstein , Jay M Young, Jerome Fischer.Vardenafil, a New Phosphodiesterase Type 5 Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes: A Multicenter Double-Blind Placebo-Controlled Fixed-Dose Study.Diabetes Care. 2003 Mar;26(3):777-83. 2. Saenz de Tejada, I., et al., The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 2001. 13(5): p. 282-90.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library FDA-Approved Drug Library Approved Drug Library Anti-Alzheimer's Disease Compound Library Inhibitor Library Drug Repurposing Compound Library

Related Products

Related compounds with same targets
BC 11-38 Tadalafil N-Methylbenzamide BI 1015550 Proxyphylline Cilostazol RS-25344 hydrochloride RS-25344

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Keywords

Vardenafil hydrochloride 224785-91-5 Metabolism PDE Vardenafil Hydrochloride PDE-5 inhibitors Vardenafil Endogenous Metabolite diabetes Zucker diabetic fatty (ZDF) rats dysfunction erectile dysfunction Pharmacokinetics Phosphodiesterase (PDE) inhibit selective Impotence Inhibitor smooth erectile muscle stimulation cGMP hepatitis inhibitor

 

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