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Vebicorvir

Catalog No. T9225   CAS 2090064-66-5
Synonyms: ABI-H0731

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

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Vebicorvir Chemical Structure
Vebicorvir, CAS 2090064-66-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 128.00
10 mg In stock $ 213.00
25 mg In stock $ 355.00
50 mg In stock $ 497.00
100 mg In stock $ 693.00
200 mg In stock $ 982.00
500 mg In stock $ 1,450.00
1 mL * 10 mM (in DMSO) In stock $ 133.00
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Purity: 99.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
In vitro ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication.
Synonyms ABI-H0731
Molecular Weight 467.44
Formula C19H12F3N3O4S2
CAS No. 2090064-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (128.36 mM)

TargetMolReferences and Literature

1. Huang Q, Cai D, Yan R, Li L, Zong Y, Guo L, Mercier A, Zhou Y, Tang A, Henne K, Colonno R. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20. 2. Smolders EJ, Burger DM, Feld JJ, Kiser JJ. Review article: clinical pharmacology of current and investigational hepatitis B virus therapies. Aliment Pharmacol Ther. 2020 Jan;51(2):231-243. doi: 10.1111/apt.15581. Epub 2019 Dec 16. 3. Yuen MF, Agarwal K, Gane EJ, Schwabe C, Ahn SH, Kim DJ, Lim YS, Cheng W, Sievert W, Visvanathan K, Ruby E, Liaw S, Yan R, Huang Q, Colonno R, Lopatin U. Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial. Lancet Gastroenterol Hepatol. 2020 Feb;5(2):152-166.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Clinical Compound Library Anti-Viral Compound Library NO PAINS Compound Library Anti-Infection Compound Library Bioactive Compound Library

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Keywords

Vebicorvir 2090064-66-5 Microbiology/Virology HBV antiviral Inhibitor inhibit ABI-H0731 Hepatitis B virus ABI-H 0731 CHB ABI-H-0731 DBT inhibitor

 

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