Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 355.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 693.00 | |
200 mg | In stock | $ 982.00 | |
500 mg | In stock | $ 1,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity. |
In vitro | ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication. |
Synonyms | ABI-H0731 |
Molecular Weight | 467.44 |
Formula | C19H12F3N3O4S2 |
CAS No. | 2090064-66-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (128.36 mM)
You can also refer to dose conversion for different animals. More
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Vebicorvir 2090064-66-5 Microbiology/Virology HBV antiviral Inhibitor inhibit ABI-H0731 Hepatitis B virus ABI-H 0731 CHB ABI-H-0731 DBT inhibitor