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Venlafaxine hydrochloride

Catalog No. T0472 CAS 99300-78-4

Synonyms: Venlafaxine HCl, Wy 45030 hydrochloride

Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Venlafaxine hydrochloride Chemical Structure

Venlafaxine hydrochloride, CAS 99300-78-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 72.00
100 mg	In stock	$ 98.00
200 mg	In stock	$ 167.00
500 mg	In stock	$ 278.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.69%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
In vitro	In mice, the analgesic effect induced by Venlafaxine is significantly inhibited by naloxone, nor-BNI, and naltrexone indol, indicating involvement of kappa (κ-) and delta (δ-) opioid mechanisms, but not by β-FNA or naloxazone. In fully developed neuropathic rats, Venlafaxine reverses hyperalgesia. Venlafaxine demonstrates a dose-dependent analgesic effect with an ED50 of 46.7 mg/kg in mice.
In vivo	Venlafaxine exhibits lower potential for inhibiting the metabolism of CYP2D6 substrates compared to widely used SSRIs such as desipramine and imipramine and can also inhibit the metabolism of several other major human hepatic P450 substrate enzymes. It inhibits the binding to human noradrenaline and serotonin transporters with K(i) values of 2480 nM and 82 nM, respectively. Furthermore, venlafaxine blocks p-chloroamphetamine and 6-hydroxydopamine-induced monoamine depletion with ED(50) values of 5.9 mg/kg and 94 mg/kg.

Synonyms	Venlafaxine HCl, Wy 45030 hydrochloride
Molecular Weight	313.863
Formula	C17H28ClNO2
CAS No.	99300-78-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 31.4 mg/mL (100 mM)

DMSO: 15.7 mg/mL (50 mM)

References and Literature

1. Ball SE, et al. Br J Clin Pharmacol, 1997, 43(6), 619-626. 2. Bymaster FP, et al. Neuropsychopharmacology, 2001, 25(6), 871-880. 3. Schreiber S, et al. Neurosci Lett, 1999, 273(2), 85-88. 4. Lang E, et al. Pain, 1996, 68(1), 151-155. 5. Jiang Bo, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway [J]. Biological psychiatry. 2019 Apr 15;85(8):650-666.

Citations

1. Jiang B, Wang H, Wang J L, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biological Psychiatry. 2019, 85(8): 650-666

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Inhibitor Library CNS-Penetrant Compound Library Anti-Obesity Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

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