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Verdinexor

Catalog No. T6123 CAS 1392136-43-4

Synonyms: KPT-335

Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Verdinexor, CAS 1392136-43-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 68.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 359.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 953.00
1 mL * 10 mM (in DMSO)	In stock	$ 125.00

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Purity: 99.93%

Purity: 98.79%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.
In vitro	In a model of autosomal dominant polycystic kidney disease, intraperitoneal injection of Verdinexor (5 mg/kg) weakened cyst growth by inhibiting XPO1. Administering Verdinexor orally (25 mg/kg) twice daily reduced the incidence and mortality of lung disease associated with lethal influenza A virus type, primarily by decreasing the expression of pro-inflammatory cytokines in the lungs, which in turn reduced pulmonary viral titers, thereby exhibiting antiviral activity.
In vivo	In Jurkat,OCI-Ly3,OCI-Ly10,和CLBL1 cells,Verdinexor inhibited cell viability with IC50 of 0.3 nM, 2.1 nM, 41.8 nM, and 8.5 nM, respectively. In Primary Canine DLBCL Cells and CLBL1 expressed XPO1 and SINE, KPT-335 induces apoptosis. Verdinexorpotently inhibits a variety of influenza virus strains, including the H1N1 epidemic virus, the highly pathogenic H5N1 bird flu virus, and the recently emerging H7N9 strain.
Cell Research	Cell viability for lymphoid lines is determined by the MTS assay using CellTiter 96? AQueous One Solution Cell Proliferation Assay Kit. Briefly, for lymphoid cell lines, 5×104 cells (or 1×105 primary DLBCL cells) are cultured in 100 μL of complete medium in 96-well plates in the presence of SINE compounds. After 72 hours, 20 μL of MTS solution is added to each well and cells are incubated for another 4 hours before measuring absorbance at 490 nm using a Wallac Victor 1420 Multilabel Counter. The IC50 of SINE is calculated using Prism 6 software. For the non-lymphoid cell lines, 96 well plates are seeded in triplicate in 90 μL with 2500 cells/well of OSA16, 5000 cells/well of C2, and 2500 cells/well of 323610-3. Seeded plates are cultured overnight then treated the following day with 10 μL of KPT-214 in C10 media at concentrations of 0.0001, 0.01, 0.1, 1.0, and 10 μM. Plates are collected at 92 hours, centrifuged at 1300 rpm, and supernatant is removed by inverting plates on absorbent paper. Plates are then sealed and immediately placed at ?80°C for a minimum of 12 hours. Plates are then thawed and CyQUANT ?Cell Proliferation Assay is performed following the manufacturer's protocol. Briefly, 200 μL of the diluted working CyQUANT solution is added to each well and protected from light. Fluorescence is the measured using a SpectraMax M2 microplate reader at 480 nm excitation and 520 nm emission. Results are represented as percent of control, or plotted to calculate IC50 values at 92 hours.(Only for Reference)

Synonyms	KPT-335
Molecular Weight	442.32
Formula	C18H12F6N6O
CAS No.	1392136-43-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82 mg/mL (185.4 mM)

Ethanol: 9 mg/mL (20.3 mM)

References and Literature

1. London CA, et al. PLoS One. 2014, 9(2), e87585. 2. Perwitasari O, et al. J Virol. 2014, 88(17), 10228-10243. 3. Tan M, et al. Am J Physiol Renal Physiol. 2014, 307(11), F1179-F1186.

Citations

1. Ou L, Wang X, Cheng S, et al. Verdinexor, a Selective Inhibitor of Nuclear Exportin 1, Inhibits the Proliferation and Migration of Esophageal Cancer via XPO1/c-Myc/FOSL1 Axis. International Journal of Biological Sciences. 2022, 18(1): 276-291.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Fluorochemical Library Bioactive Compound Library Anti-COVID-19 Compound Library Ion Channel Inhibitor Library Orally Active Compound Library ReFRAME Related Library

Related Products

Related compounds with same targets

CRM1-IN-1 KPT330,(E)- KPT185 CRM1-IN-2 Leptomycin A Selinexor (KPT-330) KPT276 LFS-1107

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Keywords

Verdinexor 1392136-43-4 Membrane transporter/Ion channel CRM1 KPT-335 KPT 335 KPT335 inhibitor inhibit

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