Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 549.00 |
Description | Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest. |
Targets&IC50 | PDE3:1.1 μM |
Synonyms | OPC-8212, Arkin, Piteranometozine |
Molecular Weight | 395.45 |
Formula | C22H25N3O4 |
CAS No. | 81840-15-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.95 mg/mL (9.99 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Vesnarinone 81840-15-5 Metabolism Microbiology/Virology Proteases/Proteasome HIV Protease PDE phosphodiesterase 3 OPC8212 Inhibitor OSC5 oral activity OSC4 OSC3 positive inotropic activity heart failure OPC-8212 OPC 8212 Arkin inhibit Piteranometozine Phosphodiesterase (PDE) inhibitor