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Vesnarinone

Catalog No. T3465   CAS 81840-15-5
Synonyms: OPC-8212, Arkin, Piteranometozine

Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.

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Vesnarinone Chemical Structure
Vesnarinone, CAS 81840-15-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 80.00
10 mg In stock $ 122.00
25 mg In stock $ 198.00
50 mg In stock $ 369.00
100 mg In stock $ 549.00
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Purity: 98.13%
Purity: 96.69%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.
Targets&IC50 PDE3:1.1 μM
Synonyms OPC-8212, Arkin, Piteranometozine
Molecular Weight 395.45
Formula C22H25N3O4
CAS No. 81840-15-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.95 mg/mL (9.99 mM), Sonification is recommended

TargetMolReferences and Literature

1. Katayama Y, et al. Inhibitory effects of Vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line. J Pharmacol Exp Ther. 2000 Jul;294(1):339-46. 2. Inage M, et al. Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin. Int J Biol Sci. 2009;5(4):304-10. 3. Cavusoglu E, et al. Vesnarinone: a new inotropic agent for treating congestive heart failure. J Card Fail. 1995 Jun;1(3):249-57. 4. Matsumori A, et al. Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure. Circulation. 1994 Mar;89(3):955-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Lipid Compound Library Anti-Metabolism Disease Compound Library Human Metabolite Library ReFRAME Related Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vesnarinone 81840-15-5 Metabolism Microbiology/Virology Proteases/Proteasome HIV Protease PDE phosphodiesterase 3 OPC8212 Inhibitor OSC5 oral activity OSC4 OSC3 positive inotropic activity heart failure OPC-8212 OPC 8212 Arkin inhibit Piteranometozine Phosphodiesterase (PDE) inhibitor

 

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