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Vilazodone Hydrochloride

Catalog No. T6232 CAS 163521-08-2

Synonyms: SB659746A, EMD 68843, Vilazodone HCl

Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.

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Vilazodone Hydrochloride Chemical Structure

Vilazodone Hydrochloride, CAS 163521-08-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 40.00
50 mg	In stock	$ 57.00
100 mg	In stock	$ 83.00
200 mg	In stock	$ 122.00
500 mg	In stock	$ 198.00
1 g	In stock	$ 297.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

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Purity: 100%

Purity: 99.92%

Biological Description

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Description	Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
In vitro	Vilazodone demonstrates an IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT. Vilazodone displays high affinity (pKi ≥ 9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors. [1]
In vivo	Vilazodone selectively enhances serotonergic output in the prefrontal cortex of rats. Vilazodone demonstrates anxiolytic efficacy through Behavioral evaluations in the ultrasonic vocalization model of anxiety in rats. Vilazodone also shows efficacy but at a single dose only in the forced swim test (a putative model of depression). [1] Vilazodone (1-10 mg/kg p.o.) dose-dependently displaces in vivo [3H]DASB (N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine) binding from rat cortex and hippocampus, indicating that vilazodone occupies 5-HT transporters in vivo. Vilazodone (10 mg/kg p.o.) is demonstrated to cause a 2-fold increase in extracellular 5-HT but no change in noradrenaline or dopamine levels in frontal cortex of freely moving rats. [2] Vilazodone affects stress potentiation of startle at doses above 5 mg/kg in rats. Vilazodone increases stress elevation of startle at 10 mg/kg in rats. Vilazodone (20 and 40 mg/kg) blocked stress potentiation of startle in rats. Vilazodone increases stress elevation of startle at all doses in rats. [3] vilazodone has no effect on 5-HT efflux at 100 nM but significantly decreases 5-HT efflux at 1 mM in the guinea-pig dorsal raphe nucleus. Vilazodone significantly increases the re-uptake half life for 5-HT in the guinea-pig dorsal raphe nucleus. [4]

Synonyms	SB659746A, EMD 68843, Vilazodone HCl
Molecular Weight	477.99
Formula	C26H27N5O2·HCl
CAS No.	163521-08-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.6 mg/mL (20 mM)

References and Literature

1. Dawson LA, et al. CNS Neurosci Ther, 2009, 15(2), 107-117. 2. Hughes ZA, et al. Eur J Pharmacol, 2005, 510(1-2), 49-57. 3. Adamec R, et al. Eur J Pharmacol, 2004, 504(1-2), 65-77.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Cancer Drug Library GPCR Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Approved Drug Library Clinical Compound Library

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Keywords

Vilazodone Hydrochloride 163521-08-2 GPCR/G Protein Neuroscience Others 5-HT Receptor Serotonin Transporter Serotonin Receptor SERT Inhibitor inhibit SB659746A Vilazodone 5-HTT 5-hydroxytryptamine Receptor EMD-68843 EMD68843 EMD 68843 SLC6A4 Vilazodone HCl inhibitor

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