store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 50.00 | |
50 mg | In stock | $ 61.00 | |
100 mg | In stock | $ 85.00 | |
500 mg | In stock | $ 117.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine. |
Targets&IC50 | DPP-4:2.3 nM |
In vitro | In obese male Zucker rats, oral administration of Vildagliptin (10 μmol/kg, p.o.) during a glucose tolerance test increases GLP-1 levels, additionally stimulates insulin secretion, and significantly reduces fluctuations in blood glucose levels. In cynomolgus monkeys treated with Vildagliptin (1 μmol/kg, p.o.), plasma DPP-IV activity is maximally inhibited (95%) approximately 2 hours post-treatment, with inhibition >50% occurring within 30 minutes and lasting over 10 hours. In adult male Sprague-Dawley rats induced with diabetes by Streptozotocin, Vildagliptin treatment of 10 mg/kg for 32 weeks prevents nerve fiber loss. At a dosage of 60 mg/kg, Vildagliptin enhances β-cell replication and decreases apoptosis, leading to an increase in pancreatic β-cell mass, which remains elevated for 12 days post withdrawal of Vildagliptin. |
In vivo | As the most stable DPP-4 inhibitor, Vildagliptin binds to the DPP-4 S1 and S2 catalytic sites, mimicking the transition state of the P-1 site. |
Synonyms | NVP-LAF 237, LAF237 |
Molecular Weight | 303.4 |
Formula | C17H25N3O2 |
CAS No. | 274901-16-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 56 mg/mL (184.6 mM)
DMSO: 56 mg/mL (184.6 mM)
H2O: 55 mg/mL (181.3 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Vildagliptin 274901-16-5 Apoptosis Proteases/Proteasome Ubiquitination Proteasome Ferroptosis DPP-4 Dipeptidyl Peptidase Inhibitor peptidase Caco-2 cells LAF-237 NVP-LAF 237 NVP-LAF237 dipeptidyl LAF 237 DPP-IV NVP-LAF-237 antihyperglycemic DPP LAF237 inhibit inhibitor