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Voreloxin hydrochloride

Catalog No. T22456 CAS 175519-16-1

Synonyms: SNS-595 hydrochloride, Vosaroxin

Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.

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Voreloxin hydrochloride Chemical Structure

Voreloxin hydrochloride, CAS 175519-16-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 428.00
1 mL * 10 mM (in DMSO)	In stock	$ 118.00

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Purity: 99.85%

Biological Description

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Description	Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
In vitro	Voreloxin potentially inhibits the relaxation of topoisomerase II relaxation with IC50 of 3.2 μg /mL with no effect on topoisomerase II cleavage. Voreloxin has a cytotoxic activity against human tumor cell lines more potent than that of etoposide. [1] Voreloxin also has broad anti-proliferative activity in 15 cell lines, including 4 drug-resistant lines, with IC50 ranging from 0.04 to 1.155 μM. [2]
In vivo	Voreloxin (50 mg/kg i.p.) shows potent antitumor activity in mice implanted with P388 leukemia cells. [1] Voreloxin (25 mg/kg i.v.) demonstrates strong tumor growth inhibition in 10 of 11 solid tumor (ovarian, breast, melanoma, gastric, colon, and lung) xenograft models, 2 hematologic tumor xenograft models, 3 multidrug resistant tumor models and 3 murine syngeneic tumor models (Colon 26, M5076 Ovarian Sarcoma, Lewis Lung carcinoma). [2]
Cell Research	Cell lines: P388 leukemia cells. Concentrations: about 10 μg/mL. Incubation Time: 72 hours. Method: Cells are seed in a 96-well microtiter plate (0.1 mL/well), preincubated for 24 h except for P388 cells, and incubated with various concentrations of a test compound in the 5% CO2 incubator at 37℃ for 72 h. Then, 0.02 mL MTT solution (5 mg/mL) is added in each well, and a further 4 h cells culturing is carried out. The medium is removed and 0.2 mL of DMSO is added in each well to dissolve the formed formazan. The absorbance is measured using Multiskan Bichromatic.
Animal Research	Animal Models: Mice implanted with P388 leukemia cells. Dosages: about 50 mg/kg. Administration: i.p.

Synonyms	SNS-595 hydrochloride, Vosaroxin
Molecular Weight	437.9
Formula	C18H20ClN5O4S
CAS No.	175519-16-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/ml (45.67 mM)

References and Literature

1. Tsuzuki Y, et al. J Med Chem. 2004, 47(8), 2097-2109. 2. Hoch U, et al. Cancer Chemother Pharmacol. 2009, 64(1), 53-65.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library NO PAINS Compound Library Apoptosis Compound Library DNA Damage & Repair Compound Library Anti-Cancer Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Aristolactam I Furanodienone GSK2795039 ENMD-2076 Antitumor agent-97 Tetrahydropalmatine (Z)-Guggulsterone IITZ-01

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Voreloxin hydrochloride 175519-16-1 Apoptosis DNA Damage/DNA Repair Topoisomerase AG 7352 AG7352 SNS-595 Hydrochloride Inhibitor SNS595 SNS-595 hydrochloride inhibit SNS 595 Hydrochloride SNS595 Hydrochloride AG-7352 SNS-595 Voreloxin Voreloxin Hydrochloride SNS 595 Vosaroxin inhibitor

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