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Voriconazole

Catalog No. T0120 CAS 137234-62-9

Synonyms: UK-109496

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

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Voriconazole, CAS 137234-62-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 50.00
50 mg	In stock	$ 71.00
100 mg	In stock	$ 112.00
200 mg	In stock	$ 160.00
500 mg	In stock	$ 266.00
1 mL * 10 mM (in DMSO)	In stock	$ 34.00

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Purity: 99.44%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.
In vitro	Intraperitoneal administration of 5 mg/kg Voriconazole combined with 1.25 mg/kg Amphotericin B significantly reduces fungal counts in selected tissues of guinea pigs when compared to control groups. Furthermore, Voriconazole at 5 mg/kg, when combined with any dose of Caspofungin Acetate, decreases tissue fungal loads, specifically demonstrating a significant reduction in the number of positive cultures. In immunocompromised guinea pigs with pulmonary aspergillosis, Voriconazole effectively reduces pulmonary Aspergillus spp. counts, displaying superior results to those observed with Itraconazole.
In vivo	In vitro, Voriconazole exhibits greater or comparable antifungal activity against most tested molds than Itraconazole and Amphotericin B. Voriconazole effectively inhibits certain conditioned filamentous fungi and dimorphic fungi (molds), as well as yeast species. At concentrations of ≤1 μg/mL, Voriconazole can inhibit 95% of fungal strains.

Synonyms	UK-109496
Molecular Weight	349.31
Formula	C16H14F3N5O
CAS No.	137234-62-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 16 mg/mL (45.8 mM)

DMSO: 65 mg/mL (186.1 mM)

References and Literature

1. Espinel-Ingroff A, et al. J Clin Microbiol, 1998, 36(1), 198-202. 2. Diekema DJ, et al. J Clin Microbiol, 2003, 41(8), 3623-3626. 3. Kirkpatrick WR, et al. Antimicrob Agents Chemother, 2002, 46(8), 2564-2568. 4. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China[J]. Mycoses. 2019 May;62(5):450-457. 5. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

Citations

1. Ma L, Lian Y, Tang J, et al. Identification of the Anti-Fungal Drug Fenticonazole Nitrate as a Novel PPARγ-Modulating Ligand With Good Therapeutic Index: Structure-Based Screening and Biological Validation. Pharmacological Research. 2021: 105860. 2. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing. Emerging Microbes & Infections. 2019, 8(1): 531-541 3. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China. Mycoses. 2019, 62(5): 450-457

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library EMA Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Fungal Compound Library Pediatric Drug Library Bioactive Compound Library FDA-Approved Drug Library Anti-Infection Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Voriconazole 137234-62-9 Microbiology/Virology Antifungal Antifection antifungal UK-109496 UK 109496 broad-spectrum triazole Fungal murine UK109496 inhibit pulmonary Inhibitor blastomycosis inhibitor

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