Powder: -20°C for 3 years | In solvent: -80°C for 1 year
X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 271.00 | |
50 mg | In stock | $ 450.00 | |
100 mg | In stock | $ 612.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. |
Targets&IC50 | ALK:0.61 nM, MET:0.69 nM |
In vitro | Ensartinib is a selective ALK inhibitor, and provids promising advantages in terms of both Clinicalal activity and safety[1]. |
Synonyms | Ensartinib, X-396 |
Molecular Weight | 547.41 |
Formula | C25H25Cl2FN6O3 |
CAS No. | 1365267-27-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37 mg/mL (67.59 mM)
You can also refer to dose conversion for different animals. More
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X-376 1365267-27-1 Angiogenesis Tyrosine Kinase/Adaptors c-Met/HGFR ALK inhibit X 396 X376 ALK tyrosine kinase receptor Cluster of differentiation 246 X 376 X396 CD246 Ensartinib Inhibitor Anaplastic lymphoma kinase Anaplastic lymphoma kinase (ALK) X-396 inhibitor