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Xylitol

Catalog No. T0589   CAS 87-99-0
Synonyms: Adonitol, Ribitol, Xylite, D-Xylitol, Adonite

Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.

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Xylitol Chemical Structure
Xylitol, CAS 87-99-0
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Purity: 99.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
In vitro Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs[1].
In vivo Xylitol triggers the release of insulin in dogs[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug[1].
Cell Research In vitro tube formation assay:HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times. (Only for Reference)
Source
Synonyms Adonitol, Ribitol, Xylite, D-Xylitol, Adonite
Molecular Weight 152.15
Formula C5H12O5
CAS No. 87-99-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 197.2 mM

DMSO: 197.2 mM

TargetMolReferences and Literature

1. Yi EY, et al. Int J Oncol. 2013, 43(1):315-320. 2. Han SJ, et al. Clin Diagn Lab Immunol. 2015, 12(11):1285-1291. 3. Kuzuya T, et al. Endocrinology. 1969, 84(2):200-207.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Tobacco Monomer Library FDA-Approved & Pharmacopeia Drug Library Anti-Metabolism Disease Compound Library Approved Drug Library Natural Product Library Anti-Diabetic Compound Library Drug-Fragment Library

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Keywords

Xylitol 87-99-0 Autophagy Metabolism Others Endogenous Metabolite Inhibitor Adonitol Ribitol inhibit Xylite D-Xylitol Adonite inhibitor

 

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