Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
Pack Size | Availability | Price/USD | Quantity |
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100 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. |
In vitro | Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs[1]. |
In vivo | Xylitol triggers the release of insulin in dogs[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug[1]. |
Cell Research | In vitro tube formation assay:HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times. (Only for Reference) |
Source |
Synonyms | Adonitol, Ribitol, Xylite, D-Xylitol, Adonite |
Molecular Weight | 152.15 |
Formula | C5H12O5 |
CAS No. | 87-99-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 197.2 mM
DMSO: 197.2 mM
You can also refer to dose conversion for different animals. More
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Xylitol 87-99-0 Autophagy Metabolism Others Endogenous Metabolite Inhibitor Adonitol Ribitol inhibit Xylite D-Xylitol Adonite inhibitor