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Y-33075 dihydrochloride

Catalog No. T13384L CAS 173897-44-4

Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).

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Y-33075 dihydrochloride Chemical Structure

Y-33075 dihydrochloride, CAS 173897-44-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 38.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 109.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 379.00
100 mg	In stock	$ 567.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.43%

Purity: 99.1%

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Storage & Solubility Information

Description	Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
Targets&IC50	PKC:420 nM, ROCK:3.6 nM, CaMK II:810 nM
In vitro	Y-33075 (Y-39983) is a potent inhibitor of ROCK(IC50 of 3.6 nM). Y-33075 also inhibits PKC and CaMKII more potently than Y-27632(IC50s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively), whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC50s of Y-27632 and Y-33075 for PKC is 82 and 117 times those for ROCK, respectively, whereas the IC50s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively[1]. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983[2]. Y-33075 (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions[3].
In vivo	Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration in rabbits. Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration in monkeys[1]. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats[2].

Molecular Weight	353.25
Formula	C16H18Cl2N4O
CAS No.	173897-44-4

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (283.09 mM), Sonification is recommended.

H2O: 50 mg/mL (141.54 mM), Sonification is recommended.

References and Literature

1. Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 2. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. 3. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11.

Related compound libraries

This product is contained In the following compound libraries：

TGF-beta/Smad Compound Library Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Reprogramming Compound Library Wnt/Hedgehog/Notch Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Neuronal Signaling Compound Library Stem Cell Differentiation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Y-33075 dihydrochloride 173897-44-4 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling Neuroscience Stem Cells CaMK ROCK PKC Y33075 dihydrochloride Y33075 Y 33075 Dihydrochloride ROK Rho-associated kinase Y-33075 Y-33075 Dihydrochloride Y33075 Dihydrochloride Inhibitor Rho-associated protein kinase Y 33075 dihydrochloride Rho-kinase inhibit Y 33075 inhibitor

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