Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 463.00 | |
50 mg | In stock | $ 683.00 | |
100 mg | In stock | $ 973.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. |
Targets&IC50 | GRP78:1.5 μM |
In vitro | YUM70, inhibited pancreatic cancer cell growth in vitro.YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis.?A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. |
In vivo | YUM70 in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.YUM70 is a novel inducer of ER stress with preclinical efficacy as a monotherapy or in combination with topoisomerase and HDAC inhibitors in pancreatic cancer. |
Molecular Weight | 398.84 |
Formula | C21H19ClN2O4 |
CAS No. | 423145-35-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (250.73 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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YUM70 423145-35-1 Apoptosis Cytoskeletal Signaling Endocrinology/Hormones GPCR/G Protein Metabolism HSP GPR Heat shock proteins cancer pancreatic reticulum YUM-70 GRP78 stress-mediated inhibit protein Inhibitor glucose-regulated endoplasmic YUM 70 inhibitor