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ZD 7155 hydrochloride

Catalog No. T13390   CAS 146709-78-6

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

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ZD 7155 hydrochloride Chemical Structure
ZD 7155 hydrochloride, CAS 146709-78-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
5 mg In stock $ 122.00
10 mg In stock $ 197.00
25 mg In stock $ 372.00
50 mg In stock $ 578.00
100 mg In stock $ 833.00
1 mL * 10 mM (in DMSO) In stock $ 127.00
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Purity: 99.23%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
In vivo ZD 7155 (240 ng/kg ; 10 min infusion ; SD rats) is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.[1]
ZD 7155 (1.082 μmol/kg ; administered intravenously) and angiotensin II given at 240 ng/kg (in a 10-min infusion) could suppress the angiotensin II-induced pressor response.[1]
ZD 7155 (1.082 mumol/kg ; conscious SHRs) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect.[1]
Molecular Weight 474.98
Formula C26H27ClN6O
CAS No. 146709-78-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 3.8 mg/mL (7.9 mM ), ultrasonic and warming and heat to 60°C

DMSO: 225.0 mg/mL (473.7 mM ), sonification is recommended.

TargetMolReferences and Literature

1. Junggren IL, et al. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J Pharm Pharmacol. 1996 ; 48(8): 829-833.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max

Related Products

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Azilsartan [Sar1, Ile8]-Angiotensin II Tranilast TRV-120027 TFA ANGIOTENSIN IV TFA(12676-15-2(free base)) L-162,313 Trans-Tranilast Olodanrigan

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Keywords

ZD 7155 hydrochloride 146709-78-6 Endocrinology/Hormones RAAS ZD 7155(hydrochloride) ZD7155 Hydrochloride ZD 7155 Hydrochloride ZD-7155 Hydrochloride inhibitor inhibit

 

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