Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 94.00 | |
5 mg | Inquiry | $ 197.00 | |
10 mg | Inquiry | $ 324.00 |
Description | Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. |
Molecular Weight | 1928.4 |
Formula | C90H154N30O17 |
CAS No. | 863987-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 1 mg/mL
You can also refer to dose conversion for different animals. More
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ZIP 863987-12-6 inhibitor inhibit