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ZL006

Catalog No. T17293 CAS 1181226-02-7

ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.

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ZL006, CAS 1181226-02-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 315.00
100 mg	In stock	$ 539.00
200 mg	In stock	$ 778.00
500 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
In vitro	ZL006 growth inhibition of BCECs is not found at a low concentration of 0.001, 0.01, 0.1, 1, and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is obviously enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs [1][2].
In vivo	T7-P-LPs/ZL006 displays a significant enhance in drug accumulation in the brain tissue due to its better brain targeting delivery compared with P-LPs/ZL006 and free ZL006. P-LPs/ZL006 and T7-P-LPs/ZL006 show a significant decrease in drug accumulation in the liver and kidney compared with free ZL006 [1].

Molecular Weight	328.15
Formula	C14H11Cl2NO4
CAS No.	1181226-02-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29 mg/mL (88.37 mM)

References and Literature

1. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651. 2. Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.

Citations

1. Yang L, Cui J, Zeng L, et al. Targeting PSD95/nNOS by ZL006 alleviates social isolation-induced heightened attack behavior in mice. Psychopharmacology. 2021: 1-10. 2. Yang L, Cui J, Zeng L, et al. Targeting PSD95/nNOS by ZL006 alleviates social isolation-induced heightened attack behavior in mice. Psychopharmacology. 2021: 1-10.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Ion Channel Inhibitor Library Antidepressant Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library PPI Inhibitor Library Anti-Parkinson's Disease Compound Library

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Keywords

ZL006 1181226-02-7 Membrane transporter/Ion channel Neuroscience NMDAR iGluR Ionotropic glutamate receptors ZL 006 Inhibitor inhibit ZL-006 inhibitor

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