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ZL0580

Catalog No. T13974   CAS 2377151-10-3

ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

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ZL0580 Chemical Structure
ZL0580, CAS 2377151-10-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 38.00
2 mg In stock $ 54.00
5 mg In stock $ 89.00
10 mg In stock $ 155.00
25 mg In stock $ 288.00
50 mg In stock $ 425.00
100 mg In stock $ 628.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
In vitro In PBMCs of viremic HIV-infected individuals,ZL0580 (8 μM, 2 days) induces HIV transcriptional suppression with low toxicity[1]. ZL0580 treatment (10 μM) suppresses both PMA-stimulated and basal HIV transcription[1].
Molecular Weight 532.53
Formula C25H23F3N4O4S
CAS No. 2377151-10-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (469.46 mM), sonification is recommended.

TargetMolReferences and Literature

1. Niu Q, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019 Jul 22;129(8):3361-3373. 2. Vansant G, et al. Block-And-Lock Strategies to Cure HIV Infection. Viruses. 2020 Jan 10;12(1). pii: E84. 3. Brasier AR, et al. Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling. Drug Discov Today. 2020 Jan;25(1):126-132.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Epigenetics Compound Library Bioactive Compound Library Anti-Viral Compound Library Inhibitor Library Anti-Infection Compound Library Kinase Inhibitor Library Histone Modification Compound Library PPI Inhibitor Library Covalent Inhibitor Library

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Keywords

ZL0580 2377151-10-3 Chromatin/Epigenetic Microbiology/Virology Proteases/Proteasome Epigenetic Reader Domain HIV Protease HIV Inhibitor ZL-0580 ZL 0580 Human immunodeficiency virus low inhibit PBMC toxicity inhibitor

 

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