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Zalcitabine

Catalog No. T0110   CAS 7481-89-2
Synonyms: Dideoxycytidine, ddC, NSC 606170, Ro 24-2027/000, 2',3'-Dideoxycytidine

Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.

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Zalcitabine Chemical Structure
Zalcitabine, CAS 7481-89-2
Pack Size Availability Price/USD Quantity
25 mg In stock $ 30.00
50 mg In stock $ 43.00
100 mg In stock $ 61.00
200 mg In stock $ 81.00
500 mg In stock $ 129.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.78%
Purity: 99.73%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.
In vitro Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[1]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[2].
Synonyms Dideoxycytidine, ddC, NSC 606170, Ro 24-2027/000, 2',3'-Dideoxycytidine
Molecular Weight 211.22
Formula C9H13N3O3
CAS No. 7481-89-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (78.92 mM)

TargetMolReferences and Literature

1. Adkins JC, et al. Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection.Drugs. 1997 Jun;53(6):1054-80. 2. Jin MJ, et al. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2.

Related compound libraries

This product is contained In the following compound libraries:
Human Metabolite Library Anti-COVID-19 Compound Library Bioactive Compounds Library Max Clinical Compound Library FDA-Approved Drug Library Anti-Infection Compound Library Anti-Viral Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Pediatric Drug Library

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Keywords

Zalcitabine 7481-89-2 Microbiology/Virology Proteases/Proteasome Reverse Transcriptase HIV Protease Dideoxycytidine NSC606170 NSC-606170 inhibit ddC Human immunodeficiency virus NSC 606170 HIV Ro 24-2027/000 2',3'-Dideoxycytidine Inhibitor inhibitor

 

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