Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 43.00 | |
100 mg | In stock | $ 61.00 | |
200 mg | In stock | $ 81.00 | |
500 mg | In stock | $ 129.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain. |
In vitro | Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[1]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[2]. |
Synonyms | Dideoxycytidine, ddC, NSC 606170, Ro 24-2027/000, 2',3'-Dideoxycytidine |
Molecular Weight | 211.22 |
Formula | C9H13N3O3 |
CAS No. | 7481-89-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (78.92 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zalcitabine 7481-89-2 Microbiology/Virology Proteases/Proteasome Reverse Transcriptase HIV Protease Dideoxycytidine NSC606170 NSC-606170 inhibit ddC Human immunodeficiency virus NSC 606170 HIV Ro 24-2027/000 2',3'-Dideoxycytidine Inhibitor inhibitor