Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 107.00 | |
5 mg | In stock | $ 228.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 716.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,370.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 253.00 |
Description | Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3). |
Targets&IC50 | PDE4D7:7.8 nM, PDE4D3:7.4 nM |
In vivo | BPN14770 increases brain cAMP increases phosphorylation of CREB and increases the production of brain-derived neurotrophic factor (BDNF) in the hippocampus [1]. BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition at doses above 0.3 mg/kg [2]. |
Synonyms | BPN14770 |
Molecular Weight | 405.8 |
Formula | C21H15ClF3NO2 |
CAS No. | 1606974-33-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 260 mg/mL (640.71 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Zatolmilast 1606974-33-7 Metabolism Others PDE Phosphodiesterase (PDE) Inhibitor BPN14770 BPN-14770 BPN 14770 inhibit inhibitor