store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zatosetron maleate(LY 277359 maleate) is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 700.00 | |
5 mg | In stock | $ 1,800.00 |
Description | Zatosetron maleate(LY 277359 maleate) is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine. |
In vivo | Acute administration of Zatosetron maleate at doses of 0.1 mg/kg (n=21) and 0.3 mg/kg (n=5) significantly reduces the activity of A10 dopamine cells in male rats, an effect not observed with doses of 0.01, 0.05, 1.0, or 10 mg/kg or with saline administration. The reduction in active A10 dopamine cells begins 60 minutes post-intraperitoneal (i.p.) administration at 0.1 mg/kg, with significant decreases observed at 60-90 minutes (0.65±0.11, P=0.03, n=5), deepening at 90-120 minutes (0.53±0.08, P=0.004, n=5), and stabilizing from 2 to 3 hours (0.50±0.05, P=0.0004, n=5). Single-unit recordings reveal that intravenous (i.v.) administration of Zatosetron maleate inhibits A10 dopamine cell activity with an ED50 of 0.12 mg/kg (n=8). Chronic administration at 0.1 mg/kg (n=16) also leads to a significant decrease in active A10 dopamine cells, with no significant effect at doses of 0.01, 1.0, or 10 mg/kg or with saline (n=4, 8, 7, and 5, respectively). |
Synonyms | LY 277359 maleate |
Molecular Weight | 464.94 |
Formula | C23H29ClN2O6 |
CAS No. | 123482-23-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Zatosetron maleate 123482-23-5 GPCR/G Protein Neuroscience 5-HT Receptor Zatosetron Maleate LY 277359 Maleate LY277359 Maleate LY 277359 maleate LY-277359 Maleate inhibitor inhibit