Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 37.00 | |
10 mg | In stock | $ 50.00 | |
25 mg | In stock | $ 85.00 | |
50 mg | In stock | $ 135.00 | |
100 mg | In stock | $ 169.00 | |
500 mg | In stock | $ 418.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
Targets&IC50 | 5-HT2A:0.42 nM (Ki), 5-HT1A receptor (human):2.5 nM (Ki), D2 receptor (rat):4.8 nM (Ki), 5-HT1A receptor (rat):3.4 nM (Ki) |
In vitro | Ziprasidone exhibits an inherent protective mechanism against drug-induced increases in food intake, demonstrated by its ability to inhibit the significant enhancement of food consumption caused by olanzapine in rats. It also induces a notable upregulation of NGF and ChAT immunoreactivity in the hippocampal regions dentate gyrus, CA1, and CA3 of rats. Furthermore, Ziprasidone dose-dependently decreases the activity of midbrain central tegmental field neurons (ED50 = 300 mg/kg i.v.), similar to atypical antipsychotics like clozapine (ED50 = 250 mg/kg i.v.) and olanzapine (ED50 = 1000 mg/kg i.v.) in anesthetized rats. In Xenopus oocytes, Ziprasidone displays a lower inhibitory effect (IC50 = 2.8 mM) on the wild-type hERG current. |
In vivo | Ziprasidone blocks wild-type hERG currents in a voltage and concentration-dependent manner with an IC(50) of 120 nM in stably transfected HEK-293 cells. Minimal hERG current blockade by ziprasidone is estimated during depolarized voltages (-20 or +30 mV) or assessed via envelope of tail test (+30 mV). The compound significantly prolongs the time constant of the slow component of hERG current deactivation at -50 mV. Ziprasidone acts as a 5-HT(1A) receptor agonist and antagonizes 5-HT(2A), 5-HT(2C), and 5-HT(1B/1D) receptors, similar to the antidepressant imipramine in inhibiting serotonin and norepinephrine neuronal uptake. It also exhibits high affinity for human 5-HT receptors and dopamine D(2) receptors. |
Synonyms | CP-88059 hydrochloride, CP-88059, Ziprasidone HCl |
Molecular Weight | 449.4 |
Formula | C21H22CL2N4OS |
CAS No. | 122883-93-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83 mg/mL (184.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Ziprasidone hydrochloride 122883-93-6 GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Dopamine Receptor Norepinephrine Histamine Receptor Adrenergic Receptor neuronal inhibit uptake rats Serotonin Receptor antipsychotic CP 88059 Hydrochloride CP-88059 hydrochloride 5-hydroxytryptamine Receptor CP88059 CP 88059 CP88059 Hydrochloride CP-88059 Hydrochloride CP-88059 Ziprasidone norepinephrine Ziprasidone HCl Sprague-Dawley Inhibitor Ziprasidone Hydrochloride inhibitor