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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate

Catalog No. TP1931L1 CAS TP1931L1

Synonyms: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces Apoptosis and inhibits cancer cell growth in vitro.

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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate, CAS TP1931L1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

Synonyms	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)
Molecular Weight	1576.91
Formula	C81H113N19O14
CAS No.	TP1931L1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2.5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Holst et al (2003) High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol.Endocrinol. 17 2201 PMID: 2. Jarpe et al (1998) [D-Arg1, D-Phe5, D-Trp7,9, Leu11] Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J.Biol.Chem. 273 3097 PMID: 3. Reeve and Bleehen (1994) [D-Arg1, D-Phe5, D-Trp7,9, Leu11] Substance P induces apoptosis in lung cancer cells in vitro. Biochem.Biophys.Res.Commun. 199 1313 PMID:

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Keywords

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate TP1931L1 GPCR/G Protein cholecystokinin [D Arg1,D Phe5,D Trp7,9,Leu11] Substance P acetate [D-Arg-1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base) [DArg1,DPhe5,DTrp7,9,Leu11]Substance P acetate Inhibitor inhibitor inhibit

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