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[Leu5]-Enkephalin

Catalog No. T7173 CAS 58822-25-6

Synonyms: Leucine enkephalin, Leucyl-enkephalin, Leu-enkephalin

[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)

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[Leu5]-Enkephalin, CAS 58822-25-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 143.00
100 mg	In stock	$ 209.00

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)
In vivo	[Leu5]-Enkephalin is found in the brain, the brainstem, and the spinal cord as well as in the peripheral nervous system. Leu-Enkephalin (1 mg/kg) decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension[1].

Synonyms	Leucine enkephalin, Leucyl-enkephalin, Leu-enkephalin
Molecular Weight	555.62
Formula	C28H37N5O7
CAS No.	58822-25-6

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (269.97 mM)

References and Literature

1. Fabisiak A , Małgorzata Sobocińska, Elżbieta Kamysz, et al. Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension - proof of concept[J]. Chemical Biology & Drug Design, 2018, 92(1). 2. Meunier J C , Moisand C . Binding of leu5-enkephalin and met5-enkephalin to a particulate fraction from rat cerebrum[J]. Febs Letters, 1977, 77(2):0-213.

Related Products

Related compounds with same targets

Alvimopan beta-Neoendorphin acetate(77739-21-0 free base) Ac-RYYRIK-NH2 acetate Difelikefalin acetate [Leu5]-Enkephalin acetate(58822-25-6 free base) DuP 747 HCl Methylnaltrexone bromide ML-335

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

[Leu5]-Enkephalin 58822-25-6 Endocrinology/Hormones GPCR/G Protein Metabolism Neuroscience Opioid Receptor Endogenous Metabolite [Leu5] Enkephalin [Leu5]Enkephalin Leucine enkephalin [Leu-5]-Enkephalin Inhibitor inhibit Leucyl-enkephalin Leu-enkephalin inhibitor

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