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Aldoxorubicin hydrochloride

Catalog No. T11090L1   CAS 1361563-03-2
Synonyms: Aldoxorubicin hydrochloride (1361644-26-9 Free base)

Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.

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Aldoxorubicin hydrochloride Chemical Structure
Aldoxorubicin hydrochloride, CAS 1361563-03-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 57.00
2 mg In stock $ 77.00
5 mg In stock $ 117.00
10 mg In stock $ 155.00
25 mg In stock $ 313.00
50 mg In stock $ 466.00
100 mg In stock $ 683.00
500 mg In stock $ 1,450.00
1 mL * 10 mM (in DMSO) In stock $ 211.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.
In vitro Aldoxorubicin hydrochloride (0.27 to 2.16 μM) inhibits formation of blood vessel and reduces growth of multiple myeloma cell in a pH-dependent fashion[1].
In vivo Aldoxorubicin hydrochloride (10.8 mg/kg, i.v.) exhibits significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1]. Aldoxorubicin hydrochloride exhibits a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study[2]. Aldoxorubicin hydrochloride exhibits superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models[3].
Synonyms Aldoxorubicin hydrochloride (1361644-26-9 Free base)
Molecular Weight 787.21
Formula C37H43ClN4O13
CAS No. 1361563-03-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.87 mg/mL (10 mM)

TargetMolReferences and Literature

1. Eric Sanchez, et al. Anti-Myeloma Effects of the Novel Anthracycline Derivative INNO-206. Clin Cancer Res.2012 18; 3856. 2. Kratz, F. INNO-206 (DOXO-EMCH), an Albumin-Binding Prodrug of Doxorubicin Under Development for Phase II Studies. Current Bioactive Compounds, 2011, 7(1): 33-38(6) 3. Graeser R, et al. INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model. Invest New Drugs. 2010 F 4. Walker L, et al. Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative. Int J Pharm. 2012 Oct 15;436(1-2):825-32.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Topoisomerase I inhibitor 9 Pyronaridine tetraphosphate Marbofloxacin Topoisomerase I inhibitor 10 Pixantrone dimaleate NH2-methylpropanamide-Exatecan TFA Aurintricarboxylic acid Cardioxane

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Keywords

Aldoxorubicin hydrochloride 1361563-03-2 DNA Damage/DNA Repair Topoisomerase Aldoxorubicin hydrochloride (1361644-26-9 Free base) Aldoxorubicin Hydrochloride 1361644-26-9 Free base 1361644-26-9 inhibitor inhibit

 

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