Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 57.00 | |
2 mg | In stock | $ 77.00 | |
5 mg | In stock | $ 117.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 466.00 | |
100 mg | In stock | $ 683.00 | |
500 mg | In stock | $ 1,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 211.00 |
Description | Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models. |
In vitro | Aldoxorubicin hydrochloride (0.27 to 2.16 μM) inhibits formation of blood vessel and reduces growth of multiple myeloma cell in a pH-dependent fashion[1]. |
In vivo | Aldoxorubicin hydrochloride (10.8 mg/kg, i.v.) exhibits significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1]. Aldoxorubicin hydrochloride exhibits a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study[2]. Aldoxorubicin hydrochloride exhibits superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models[3]. |
Synonyms | Aldoxorubicin hydrochloride (1361644-26-9 Free base) |
Molecular Weight | 787.21 |
Formula | C37H43ClN4O13 |
CAS No. | 1361563-03-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.87 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Aldoxorubicin hydrochloride 1361563-03-2 DNA Damage/DNA Repair Topoisomerase Aldoxorubicin hydrochloride (1361644-26-9 Free base) Aldoxorubicin Hydrochloride 1361644-26-9 Free base 1361644-26-9 inhibitor inhibit