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antcin A

Catalog No. TN7099   CAS 163597-24-8

antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.

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antcin A Chemical Structure
antcin A, CAS 163597-24-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 148.00
5 mg In stock $ 336.00
10 mg In stock $ 497.00
25 mg In stock $ 793.00
50 mg In stock $ 1,130.00
1 mL * 10 mM (in DMSO) In stock $ 396.00
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Purity: 96.43%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.
In vitro Antcin A could significantly inhibit the occurrence of pyrolysis, decrease the expression of inflammatory factors, inhibit the activation and assembly of NLRP3 inflammasome, and significantly down-regulate the expression of NLRP3, Caspase-1 and GSDMD-NT in KCs[1].
In vivo In NAFLD mice, Antcin A could suppress the inflammatory response in liver tissues of mice, reduce lipid deposition, down-regulate the levels of ALT and AST, and improve liver function in mice. Antcin A could also inhibit the activation of NLRP3 inflammasome in liver tissue and decrease the level of inflammatory factors[1].
Molecular Weight 454.64
Formula C29H42O4
CAS No. 163597-24-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (109.98 mM)

TargetMolReferences and Literature

1. Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126. 2. Kumar KJS, et al. Antcin-A Modulates Epithelial-to-Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53-Mediated miR-200c Activation. Planta Med. 2019 Jul;85(9-10):755-765.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Breast Cancer Compound Library Pyroptosis Compound Library Anti-Cancer Active Compound Library Antiparasitic Natural Product Library Natural Product Library for HTS

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ADS032 Bergenin Procyanidin B2 MCC950 Molsidomine NLRP3-IN-11 Selnoflast CY-09

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Keywords

antcin A 163597-24-8 Immunology/Inflammation NF-Κb NOD inhibitor inhibit

 

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