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Description | Boc-NH-PEG4-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Alias | Boc-NH-PEG4-C2-Boc |
Molecular Weight | 421.531 |
Formula | C20H39NO8 |
Cas No. | 2138484-13-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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