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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | Inquiry | Backorder |
Description | C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. |
Molecular Weight | 1052.391 |
Formula | C54H101NO18 |
Cas No. | 69283-33-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Methanol: Warmed Chloroform:Methanol (2:1): Soluble DMSO: Soluble |
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