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Chondroitin sulfate

Chondroitin sulfate
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Purity:99.87%
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Chondroitin sulfate

Catalog No. T2980Cas No. 9007-28-7
Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
500 mg$47In Stock
1 g$56In Stock
5 g$133In Stock
10 g$198In Stock
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Product Introduction

Bioactivity
Description
Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition
In vitro
Chondroitin sulfate, a sulfated glycosaminoglycan comprising linear polysaccharides with repeating disaccharide units of uronic acid and N-acetylhexosamine, plays a critical role in the extracellular matrix of various connective tissues, including bone, cartilage, skin, ligaments, and tendons. It has been observed that various pathogens such as parasites, bacteria, and viruses exploit chondroitin sulfate on the cell surface for host cell attachment and infection. Beyond its natural occurrence, chondroitin sulfate exhibits multiple beneficial properties, including anti-inflammatory effects, promotion of type II collagen and proteoglycan production, reduction in bone resorption, and support for a positive anabolic/catabolic balance in chondrocytes. In vitro studies have employed a broad spectrum of chondroitin sulfate concentrations, typically not exceeding 200 mg/mL, demonstrating its capability to diminish chondrocyte vulnerability to apoptosis triggered by single nucleotide polymorphism at 200 mg/mL concentration. Moreover, it significantly lowers the levels of inflammation mediators, the apoptotic process, and inflammatory cytokine, iNOS, and MMPs production.
In vivo
The high content of chondroitin sulfate in aggrecan significantly contributes to cartilage's ability to withstand tensile stresses under various loading conditions, endowing the tissue with enhanced resistance and elasticity. Research indicates that chondroitin sulfate plays a role in mitigating the progression of structural changes in joint tissues, thereby supporting its use in treating osteoarthritis patients. Administered orally in dosages between 800 to 1200 mg/day, chondroitin sulfate is quickly absorbed by the gastrointestinal tract. Once absorbed, it enters the bloodstream as 10% unchanged chondroitin sulfate and 90% as depolymerized low-molecular-weight derivatives.
Cell Research
Chondrocytes are cultured into six-well culture plates. 12 hours after plating, the culture medium is replaced with 2.0 mL of fresh medium containing LPS at a concentration of 50 mg/mL. 4 hours later, HA, Chondroitin sulfate, HS, keratan sulphate and DS are added separately to each of the wells at concentrations of 0.5 and 1.0 mg/mL. The number of viable chondrocytes is then quantified by trypan blue dye exclusion test from several randomly chosen areas of each well[4].
AliasChonsurid, Chondroitin polysulfate
Chemical Properties
Molecular Weight3-5w kDa
Formula(C14H21NO14S)n
Cas No.9007-28-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: Slightly soluble

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