Powder: -20°C for 3 years | In solvent: -80°C for 1 year
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 96.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 347.00 | |
25 mg | In stock | $ 589.00 | |
50 mg | In stock | $ 842.00 | |
100 mg | In stock | $ 1,160.00 |
Description | dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. |
In vitro | Treatment of the human haploid cell line HAP1 for 6 h with dCBP-1 revealed almost complete loss of both CBP and p300 between 10 and 1,000 nM doses. A time course analysis with 250 nM dCBP-1 revealed almost complete degradation of p300/CBP within an hour of treatment[1]. dCBP-1 was also able to induce near-complete p300/CBP degradation across other multiple myeloma cell lines tested, including MM1R, KMS-12-BM, and KMS34[1]. |
Molecular Weight | 1028.11 |
Formula | C51H63F2N11O10 |
CAS No. | 2484739-25-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (48.63 mM)
You can also refer to dose conversion for different animals. More
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dCBP-1 2484739-25-3 Chromatin/Epigenetic PROTAC Epigenetic Reader Domain Ligand for E3 Ligase Inhibitor p300 multiple CRBN myeloma cell degrader PROTACs MYC CBP inhibit dCBP 1 dCBP1 heterobifunctional inhibitor