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DDP-38003 trihydrochloride

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DDP-38003 trihydrochloride

Catalog No. T10983

DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.

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Pack Size	Price	Availability	Quantity
100 mg	$1,570	1-2 weeks

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Product Introduction

Bioactivity

Description	DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.
Targets&IC50	KDM1A/LSD1:84 nM
In vitro	DDP-38003 inhibits KDM1A with an IC50 of 84 nM. It is more effective in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue [1].
In vivo	DDP-38003 demonstrates effectiveness in vivo upon oral administration, leading to a 62% increase in survival rates in mouse leukemia models via KDM1A inhibition. It has a half-life of 8 hours. A notable dose-dependent enhancement in survival rates of mice treated with DDP-38003 is observed, with survival rates escalating by 35% and 62% at doses of 11.25 and 22.50 mg/kg, respectively, showcasing its potential as a cancer therapeutic [1].

Chemical Properties

Molecular Weight	459.84
Formula	C21H29Cl3N4O
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (217.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1747 mL	10.8733 mL	21.7467 mL	108.7335 mL
5 mM	0.4349 mL	2.1747 mL	4.3493 mL	21.7467 mL
10 mM	0.2175 mL	1.0873 mL	2.1747 mL	10.8733 mL
20 mM	0.1087 mL	0.5437 mL	1.0873 mL	5.4367 mL
50 mM	0.0435 mL	0.2175 mL	0.4349 mL	2.1747 mL
100 mM	0.0217 mL	0.1087 mL	0.2175 mL	1.0873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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