Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.

Dehydroisoandrosterone 3-acetate implants increases aggression in a laboratory-based simulated territorial intrusion. Brains of birds implanted with Dehydroisoandrosterone 3-acetate display higher aromatase mRNA expression in the preoptic area (POA) as well as higher androgen receptor mRNA expression in the periventricular nucleus of the medial striatum (pvMSt) and ventromedial nucleus of the hypothalamus (VMH). The Dehydroisoandrosterone 3-acetate -induced increases in aromatase expression in the POA and androgen receptor expression in the pvMSt are consistent with previously reported seasonal increases in these markers associated with naturally elevated Dehydroisoandrosterone 3-acetate levels[1]. Dehydroisoandrosterone 3-acetate supplementation (10.2 mg/kg) alone significantly increases mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group[2].