store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 168.00 | |
2 mg | In stock | $ 265.00 | |
5 mg | In stock | $ 502.00 | |
10 mg | In stock | $ 678.00 | |
25 mg | In stock | $ 1,425.00 | |
50 mg | In stock | $ 2,350.00 | |
100 mg | In stock | $ 3,560.00 |
Description | diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
Targets&IC50 | human STNG in PBMCs:130 nM (EC50) |
In vitro | diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, respectively. diABZI STING agonist-1 (Tautomerism) at a concentration of 1 μM showed high selectivity for more than 350 kinases tested[1]. |
In vivo | diABZI STING agonist-1 (Tautomerism)(subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type I interferon and proinflammatory cytokines in vivo. diABZI STING agonist-1 (Tautomerism) (intravenous; 3 mg/kg) exhibited systemic exposure with a half-life of 1.4 hours and reached a systemic concentration greater than half the maximum effective concentration of STING in mice (EC50) 200 ng/kg) ml). diABZI STING agonist-1 (Tautomerism) (intravenous; 1.5 mg / kg; 43 days) can significantly inhibit tumor growth and significantly improve survival rate (P <0.001). Eight out of 10 mice are tumor-free[1]. |
Synonyms | diABZI STING agonist (Compound 3) |
Molecular Weight | 849.94 |
Formula | C42H51N13O7 |
CAS No. | 2138498-18-5 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 126mg/mL (148.2mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
diABZI STING agonist-1 (Tautomerism) 2138498-18-5 Immunology/Inflammation STING diABZI STING agonist (Compound 3) Compound 3 diABZI STING agonist-1 diABZI STING agonist Tautomerism inhibitor inhibit