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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $110 | 35 days |
Description | GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation. |
In vitro | GSK-3β inhibitor 8 (Compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. GSK-3β inhibitor 8 (2 μM; 72 h) increases replicating R7T1 β cells approximately 2-fold.[1] GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces activation of the Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM.[1] GSK-3β inhibitor 8 (2 μM; 72 h) stimulates β-catenin translocation into the nucleus in HEK293 cells.[1] |
Alias | GSK3β Inhibitor XVIII |
Molecular Weight | 413.92 |
Formula | C20H20ClN5OS |
Cas No. | 1139875-74-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: Soluble |
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