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GSK-3β inhibitor 8
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Catalog No. T35556Cas No. 1139875-74-3
Alias GSK3β Inhibitor XVIII
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation.
GSK-3β inhibitor 8
😃Good
Catalog No. T35556Alias GSK3β Inhibitor XVIIICas No. 1139875-74-3
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $110 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation. |
| In vitro | GSK-3β inhibitor 8 (Compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. GSK-3β inhibitor 8 (2 μM; 72 h) increases replicating R7T1 β cells approximately 2-fold.[1] GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces activation of the Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM.[1] GSK-3β inhibitor 8 (2 μM; 72 h) stimulates β-catenin translocation into the nucleus in HEK293 cells.[1] |
| Alias | GSK3β Inhibitor XVIII |
| Molecular Weight | 413.92 |
| Formula | C20H20ClN5OS |
| Cas No. | 1139875-74-3 |
| Smiles | C(=O)(C1=C(Cl)C=C(NC=2N=C(C=CN2)C3=CC=CS3)C=C1)N4CCN(C)CC4 |
| Relative Density. | 1.358 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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