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MCL-1/BCL-2-IN-3

Name: MCL-1/BCL-2-IN-3
Brand: TargetMol
SKU: T11970
Rating: 4.5 (1 reviews)

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Catalog No. T11970Cas No. 2163793-55-1

MCL-1/BCL-2-IN-3 is a selective and potent dual inhibitor of Mcl-1 and Bcl-2, with IC50 values of 5.95 and 4.78 μM, respectively.

MCL-1/BCL-2-IN-3

😃Good

Catalog No. T11970Cas No. 2163793-55-1

MCL-1/BCL-2-IN-3 is a selective and potent dual inhibitor of Mcl-1 and Bcl-2, with IC50 values of 5.95 and 4.78 μM, respectively.

Pack Size	Price	Availability
2 mg	$169	6-8 weeks
5 mg	$297	6-8 weeks
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$1,860	6-8 weeks
1 mL x 10 mM (in DMSO)	$417	6-8 weeks

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Product Introduction

Bioactivity

Description

MCL-1/BCL-2-IN-3 is a selective and potent dual inhibitor of Mcl-1 and Bcl-2, with IC50 values of 5.95 and 4.78 μM, respectively.

Chemical Properties

Molecular Weight	569.47
Formula	C₂₇H₂₅BrN₂O₅S
Cas No.	2163793-55-1
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 17.86 mg/mL (31.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7560 mL	8.7801 mL	17.5602 mL	87.8009 mL
5 mM	0.3512 mL	1.7560 mL	3.5120 mL	17.5602 mL
10 mM	0.1756 mL	0.8780 mL	1.7560 mL	8.7801 mL
20 mM	0.0878 mL	0.4390 mL	0.8780 mL	4.3900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MCL 1/BCL 2 IN 3MCL-1/BCL-2-IN-3MCL1/BCL2IN3