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meso-Dihydroguaiaretic acid

Catalog No. T28021 CAS 36469-60-0

meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.

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meso-Dihydroguaiaretic acid Chemical Structure

meso-Dihydroguaiaretic acid, CAS 36469-60-0

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Biological Description

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Description

meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.

Molecular Weight	330.42
Formula	C20H26O4
CAS No.	36469-60-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lee A, Choi KM, Jung WB, Jeong H, Kim GY, Lee JH, Lee MK, Hong JT, Roh YS, Sung SH, Yoo HS. Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes. Molecules. 2017 Aug 28;22(9). pii: E1423. doi: 10.3390/molecules22091423. PubMed PMID: 28846649. 2. Reyes-Melo K, García A, Romo-Mancillas A, Garza-González E, Rivas-Galindo VM, Miranda LD, Vargas-Villarreal J, Favela-Hernández JMJ, Camacho-Corona MDR. meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity. Bioorg Med Chem. 2017 Oct 15;25(20):5247-5259. doi: 10.1016/j.bmc.2017.07.047. Epub 2017 Jul 29. PubMed PMID: 28844400. 3. Nishiwaki H, Nakazaki S, Akiyama K, Yamauchi S. Structure-Antifungal Activity Relationship of Fluorinated Dihydroguaiaretic Acid Derivatives and Preventive Activity against Alternaria alternata Japanese Pear Pathotype. J Agric Food Chem. 2017 Aug 9;65(31):6701-6707. doi: 10.1021/acs.jafc.7b01896. Epub 2017 Jul 26. PubMed PMID: 28681599. 4. Vuorinen A, Engeli RT, Leugger S, Bachmann F, Akram M, Atanasov AG, Waltenberger B, Temml V, Stuppner H, Krenn L, Ateba SB, Njamen D, Davis RA, Odermatt A, Schuster D. Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2. J Nat Prod. 2017 Apr 28;80(4):965-974. doi: 10.1021/acs.jnatprod.6b00950. Epub 2017 Mar 20. PubMed PMID: 28319389; PubMed Central PMCID: PMC5411959.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

meso-Dihydroguaiaretic acid 36469-60-0 mesoDihydroguaiaretic acid meso Dihydroguaiaretic acid inhibitor inhibit

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